Adam's Apple

Fruit polyphenols help fight free radicals that can harm testosterone production.

June 2016

by Lisa James


It wasn’t so long ago that symptoms caused by falling hormone levels at midlife were thought of as exclusively a woman’s concern. Now most people are aware that men are subject to reductions in hormone amounts, too.

While estrogen levels tend to drop steeply in women, men generally experience a more gradual loss of testosterone as they age, a phenomenon known as andropause. In some cases, this can lead to problems such as depression, fatigue, weakness and lower sex drive.

There are ways to support the body’s ability to create testosterone. One way is to use compounds found in apples and grapes to protect hormone-secreting cells in the testes from destructive oxidation.

Oxidative Attack

The testes produce not only hormones but also sperm. Testosterone plays a role in sperm production; in addition it fuels sex drive and helps build bone and muscle while also supporting positive mood, sharp mental focus and overall energy levels.

Normal cellular activity produces unstable molecules called free radicals. Their instability makes them chemically prone to reacting with virtually all types of substances within the cell, causing oxidative damage as a result. Free-radical reactions have also been found to promote low-level inflammation, which has been linked to a number of chronic diseases.

Excessive free-radical activity threatens the testes’ ability to make testosterone in adequate amounts. While the body does produce free-radical fighters called antioxidants, the toxic world we live in—including exposure to noxious chemicals, tobacco smoke and certain medications, among others—can lead to free radicals being created in amounts that overwhelm the body’s resources.

Vigorous Defense

Apples and grapes have been praised in traditional lore as wellsprings of health; modern researchers have found these fruits to contain antioxidant polyphenols. In laboratory studies, these substances have shown the potential to reduce oxidative stress and inflammation (PLOS ONE 1/13 and 1/29/15). They’ve also been found to boost endurance and decrease both blood pressure and arterial plaque formation (PLOS ONE 9/16/15, Nutrients 8/24/15).

ViNitrox is a dietary supplement ingredient that combines apple and grape polyphenols. This formulation is designed to fight a specific free radical, peroxynitrite, that has been found to reduce testosterone levels (it doesn’t help that lowering testosterone causes an increase in peroxynitrite). In an unpublished French study, ViNitrox was able to reduce fatigue and increase performance among athletes.

ViNitrox works best in conjunction with testosterone-supporting herbs. Tribulus terrestris, also known as puncture vine, is valued in Eastern medicine for increasing sperm production and correcting erectile dysfunction; it has enhanced male sex drive in clinical trials. The spice fenugreek contains compounds that have shown an ability to raise testosterone levels. And Rhodiola rosea, which helps the body deal with stress, has been noted for its ability to reduce fatigue, improve mental and physical stamina and revive a sagging libido.

Our contaminated world can be tough on testosterone. Fortunately, apple and grape polyphenols can help a man’s body fight back.

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